Valt projekt - Uppsala universitet
Kliniska studier av experimentella och kommande
Glioma stem-like cells (GSCs) are undifferentiated and self-renewing cells that develop and maintain these tumors. These cells are the main population that resist current therapies. Genomic and epigenomic analyses has identified various molecular subtypes. Bone morphogenetic protein 4 (BMP4) reduces the number of GSCs through differentiation and 2016-05-12 The most prevalent primary brain tumors are gliomas, which start in the glial cells. Although there have been significant technological advances in surgery and radio-chemotherapy, the prognosis and survival of patients with malignant gliomas remain poor.
To this end, we transfected the human glioma cell lines U87-MG and U251 with the cel-mir-67, cel-mir-239, or Luc67 plasmids and performed the same co-culture experiment. 2019-09-13 · DHA showed anticancer effects in glioma cells. We first assessed the effects of DHA on the proliferation of glioma cells. As shown in Fig. 1a, DHA treatment significantly inhibited the viability of both glioma cell lines (U251 and U373) and primary human glioma cells (G0101 and G0107) in a dose-dependent manner. Malignant gliomas are heterogeneous neoplasms.
Serglycin as a potential biomarker for glioma: association of
Single-cell analysis of tumor-infiltrating T cells in glioma patients identifies a T cell population co-expressing a cytotoxicity program and NK cell receptors. Mathewson et al. reveal the functional significance of NK cell receptors such as CD161 in inhibiting the anti-tumor function of T cells, highlighting their potential as targets for immunotherapy. 2021-01-04 · Glioblastoma (GBM) is an incurable and highly heterogeneous brain tumor, originating from human neural stem/progenitor cells (hNSCs/hNPCs) years ahead of diagnosis.
Exosomes reflect the hypoxic status of glioma cells and
The inability of free drugs to cross the blood–brain barrier and their off-target accumulation results in dose-limiting side effects. This study aimed at enhancing the encapsulation Malignant glioma cells. Glioblastoma multiforme (malignant brain tumor) cells. The cells have irregular shapes with fingers that can spread into the brain. Glioma cells secrete exosomes that contain mRNA and miRNA and promote blood vessel formation . Extracellular vesicles (EV) from gliomas were shown to deliver miR-1 to recipient cells to modify glioma cell invasion and proliferation as well as impact stromal cells to promote endothelial tube formation .
In this study we address how astrocytes, one of the most abundant cell types of the glioma microenvironment, respond to low
The infiltrative gliomas are the most common malignant brain tumors, and they the immune system and by activating it target attack on glioma cells may occur.
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Glioblastoma multiforme (GBM) is the most aggressive type of glioma. In addition, approximately half of patients with GBM died within 15 months [ 2 ].
There are three principle types of glial cells: astrocytes, oligodendrocytes and ependymal cells. Gliomas are brain tumours that start in glial cells. These are the supporting cells of the brain and the spinal cord.
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Modeling Neural Stem Cell and Glioma Biology - Diva Portal
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